phospho-Ephrin B2 (Tyr311/316),磷酸化Ephrin B2抗体

产品编号HZ-10940R
英文名称phospho-Ephrin B2 (Tyr311/316)
中文名称磷酸化Ephrin B2抗体
别 名phospho-Ephrin B2 (Tyr311+Tyr316); Ephrin B2 (phospho Y311 + Y316); CEK5 ligand; EFNB1; ELK L; EphrinB; Ephrin-B; ELK ligand; ELKL; EPH related receptor tyrosine kinase ligand 2; Ephrin B Precursor; Ephrin B1; Ephrin B2; LERK 2; LERK2; EFNB1_HUMAN; EFNB2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 神经生物学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
phospho-Ephrin B2 (Tyr311/316),磷酸化Ephrin B2抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human Ephrin B2 around the phosphorylation site of Tyr311/316)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-Ephrin B2 (Tyr311/316),磷酸化Ephrin B2抗体PubMedPubMed
产品介绍background:
Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase.

Subunit:
Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein.

Subcellular Location:
Membrane; single pass type I membrane protein.

Tissue Specificity:
Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.

Post-translational modifications:

Similarity:
Belongs to the ephrin family.
Contains 1 ephrin RBD (ephrin receptor-binding) domain.

Gene ID:
1947

phospho-Ephrin B2 (Tyr311/316),磷酸化Ephrin B2抗体Database links:
Entrez Gene: 1947 Human
Entrez Gene: 1948 Human
Entrez Gene: 13641 Mouse
Entrez Gene: 13642 Mouse
Entrez Gene: 25186 Rat
Omim: 300035 Human
Omim: 600527 Human
SwissProt: P52799 Human
SwissProt: P98172 Human
SwissProt: P52795 Mouse
SwissProt: P52800 Mouse
SwissProt: P52796 Rat
SwissProt: Q6P7B6 Rat
Unigene: 144700 Human
Unigene: 149239 Human
Unigene: 44398 Rat

phospho-Ephrin B2 (Tyr311/316),磷酸化Ephrin B2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.