FIBCD1,含纤维蛋白原C结构域蛋白1抗体

产品编号HZ-9546R
英文名称FIBCD1
中文名称含纤维蛋白原C结构域蛋白1抗体
别 名FIBCD 1; Fibrinogen C domain containing 1; Fibrinogen C domain containing protein 1; FLJ14810; FBCD1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Zebrafish, Sheep,
FIBCD1,含纤维蛋白原C结构域蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FIBCD1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FIBCD1,含纤维蛋白原C结构域蛋白1抗体PubMedPubMed
产品介绍background:
FIBCD1 is a 461 amino acid single-pass membrane protein that contains one fibrinogen C-terminal domain and exists as multiple alternatively spliced isoforms. The gene encoding FIBCD1 maps to human chromosome 9, which contains 145 million base pairs, comprises 4% of the human genome and encodes nearly 900 genes.

Function:
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.

Subunit:
Interacts with CPS1 (By similarity). Monomer. Homodimer. Forms homodimers upon suramin binding.

Subcellular Location:
Mitochondrion matrix. Mitochondrion intermembrane space.
Isoform 1: Cytoplasm. Mitochondrion.
Isoform 2: Mitochondrion.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the sirtuin family. Class III subfamily.
Contains 1 deacetylase sirtuin-type domain.

Database links:
Entrez Gene: 84929 Human
Entrez Gene: 98970 Mouse
Entrez Gene: 311861 Rat
SwissProt: Q8N539 Human
SwissProt: A2AV25 Mouse

FIBCD1,含纤维蛋白原C结构域蛋白1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.