• 经测试应用WB, IHC-Pmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Dog, Gorilla, Orangutan
• 免疫原

  This product was produced with the following immunogens:
  Synthetic peptide corresponding to Human ESE1 aa 1-16 (N terminal). NCBI Accession No. NP_004424.3.
  Sequence:

  MAATCEISNIFSNYFS

  
  Database link: P78545
  
  Synthetic peptide corresponding to Human ESE1 aa 358-371 (C terminal). NCBI Accession No. NP_004424.3.
  Sequence: SSGWKEEEVLQSRN 
  Database link: P78545

   

  Run BLAST with Run BLAST with 
  Run BLAST with Run BLAST with 
• 阳性对照
  • Human breast tissue.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
• 存储溶液Preservative: 0.02% Sodium azide
  Constituent: 99% PBS
• 浓度50 µl 浓度为 1 mg/ml 
  
• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
   
  • Transcription
   
  • Other factors

应用

靶标

• 功能Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
• 组织特异性Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
• 序列相似性Belongs to the ETS family.
  Contains 1 ETS DNA-binding domain.
  Contains 1 PNT (pointed) domain.
• 结构域the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
• 细胞定位Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.

• Anti-ESE1 antibody 图像

  • 

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESE1 antibody (ab194943)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast tissue, labeling ESE1 using ab194943 at 5 µg/mL.