• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
• 存储溶液Preservative: 0.01% Sodium azide
  Constituents: 40% Glycerol, 0.05% BSA, 59% PBS
• 浓度100 µl 浓度为 1.311 mg/ml 40 µl 浓度为 1.311 mg/ml 
  
• 纯度Protein A purified
• 克隆单克隆
• 克隆编号EP6072(2)
• 同种型IgG
• 研究领域
  • Signal Transduction
   
  • Metabolism
   
  • Energy Metabolism

  • Cardiovascular
   
  • Atherosclerosis
   
  • Lipoprotein metabolism

  • Cancer
   
  • Cancer Metabolism
   
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Metabolism
   
  • Pathways and Processes
   
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
   
  • Lipoprotein metabolism

  • Metabolism
   
  • Pathways and Processes
   
  • Metabolic signaling pathways
  • Energy transfer pathways
   
  • Energy Metabolism

  • Metabolism
   
  • Pathways and Processes
   
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
   
  • Types of disease
   
  • Heart disease

应用

靶标

• 功能Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
• 通路Lipid metabolism; leukotriene A4 biosynthesis.
• 序列相似性Belongs to the lipoxygenase family.
  Contains 1 lipoxygenase domain.
  Contains 1 PLAT domain.
• 翻译后修饰Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
• 细胞定位Cytoplasm. Nucleus matrix. Nucleus membrane. Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
• Information by UniProt
• 数据库链接
  • Entrez Gene: 477753 Dog
  • Entrez Gene: 240 Human
  • Entrez Gene: 11689 Mouse
  • Entrez Gene: 25290 Rat
  • Omim: 152390 Human
  • SwissProt: P09917 Human
  • SwissProt: P48999 Mouse
  • SwissProt: P12527 Rat

  see all
• 别名
  • 5 LO antibody
  • 5 LOX antibody
  • 5-lipoxygenase antibody

  see all

Anti-5 Lipoxygenase antibody [EP6072(2)] 图像

• 

  Immunocytochemistry/ Immunofluorescence - Anti-5 Lipoxygenase antibody [EP6072(2)] (ab169755)