Septin 8,细胞分化蛋白SEPT8抗体

产品编号HZ-6907R
英文名称Septin 8
中文名称细胞分化蛋白SEPT8抗体
别 名Nkrf; RCG53214, isoform CRA_d; SEP2; SEP 2; SEP2; SEPT 8; SEPT8; SEPT-8; Septin8; Septin 8; Septin-8; SEPT8_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞周期蛋白 细菌及病毒 细胞分化 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Cow,
Septin 8,细胞分化蛋白SEPT8抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SEPT8
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Septin 8,细胞分化蛋白SEPT8抗体PubMedPubMed
产品介绍background:
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. [provided by RefSeq, Jun 2012].

Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion.

Subunit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with CDK14, SEPT4, SEPT5 and SEPT7.

Septin 8,细胞分化蛋白SEPT8抗体Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules.

Tissue Specificity:
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.

Similarity:
Belongs to the septin family.

Database links:
UniProtKB/Swiss-Prot: Q92599.4

Septin 8,细胞分化蛋白SEPT8抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SEPTIN(SEPT)家族是细胞骨架蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与细胞的分裂、细胞膜的运输以及构成细胞骨架。