TCF12,转录因子12抗体

产品编号HZ-11237R
英文名称TCF12
中文名称转录因子12抗体
别 名bHLHb20; Class B basic helix-loop-helix protein 20; DNA binding protein HTF4; DNA-binding protein HTF4; E box binding protein; E-box-binding protein; HEB; HTF4; HTF4_HUMAN; TCF-12; Tcf12; Transcription factor 12; Transcription factor HTF-4; Transcription factor HTF4.
说 明 书0.1ml 0.2ml
研究领域转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Horse, Rabbit, Zebrafish, Sheep,
TCF12,转录因子12抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量73kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TCF12
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TCF12,转录因子12抗体PubMedPubMed
产品介绍background:
Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and hetero-oligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression.

Function:
Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems.

Subunit:
Contains 1 basic helix-loop-helix (bHLH) domain.

Subcellular Location:
Nucleus.

TCF12,转录因子12抗体Tissue Specificity:
Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line.

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

Database links:
Entrez Gene: 6938 Human
Omim: 600480 Human
SwissProt: Q99081 Human
Unigene: 511504 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.