C1D,核DNA结合蛋白C1D抗体

产品编号HZ-13800R
英文名称C1D
中文名称核DNA结合蛋白C1D抗体
别 名1110036E10Rik; AI875855; C1D; C1D DNA binding protein; C1D_HUMAN; hC1D; LRP1; MGC12261; MGC14659; MGC188504; Nuclear DNA binding protein; Nuclear nucleic acid binding protein C1D; Nuclear nucleic acid-binding protein C1D; rCG23324; RGD1560600; Small unique nuclear receptor corepressor.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞凋亡 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Monkey,
C1D,核DNA结合蛋白C1D抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human C1D
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
C1D,核DNA结合蛋白C1D抗体PubMedPubMed
产品介绍background:
C1D, also known as SUNCOR, is a nuclear DNA-binding protein that localizes to the nucleus and cytoplasm and participates in processing of the 5.8S rRNA. Expressed ubiquitously with highest expression in thyroid, salivary gland, hippocampus and medulla oblongata, C1D forms a multi-protein complex with MPP6 (M phase phosphoprotein 6) and EXOSC10 (exosome component 10). This complex is responsible, in part, for recruiting the exosome to pre-rRNA and it functions to mediate 3’-5’ rRNA processing. Additionally, C1D can induce transcriptional repression and apoptosis through interaction with Rev-erbα (V-erbA-related protein EAR-1)/TRβ (thyroid hormone receptor β) and p53, respectively. C1D, a 141 amino acid protein, is also implicated in DNA repair mechanisms, as well as DNA-PK (DNA-dependent protein kinase) activation.

Function:
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB.

Subcellular Location:
Cytoplasm. Nucleus > nucleolus. EXOSC10 is required for nucleolar localization.

Tissue Specificity:
Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon.

Post-translational modifications:
Phosphorylated by PRKDC.

Similarity:
Belongs to the C1D family.

Gene ID:
10438

Database links:
Entrez Gene: 10438 Human
Entrez Gene: 506667 Cow
Entrez Gene: 57316 Mouse
Entrez Gene: 289810 Rat
Omim: 606997 Human
SwissProt: Q32PE4 Cow
SwissProt: Q13901 Human
SwissProt: O35473 Mouse
Unigene: 87882 Cow
Unigene: 602900 Human
Unigene: 697447 Human
Unigene: 287982 Mouse

C1D,核DNA结合蛋白C1D抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.