FITC标记的胞质分裂专一蛋白7抗体
产品名称： FITC标记的胞质分裂专一蛋白7抗体
英文名称： Anti-DOCK7/FITC
产品编号： HZ-11825R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-DOCK7/FITC Conjugated antibody
FITC标记的胞质分裂专一蛋白7抗体
| 英文名称 | Anti-DOCK7/FITC |
| 中文名称 | FITC标记的胞质分裂专一蛋白7抗体 |
| 别 名 | dedicator of cytokinesis 7; Dedicator of cytokinesis protein 7; Gm430; KIAA1771 ; MGC189434; mKIAA1771; RP23 329P19.2; ZIR2; DOCK7_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 242kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DOCK7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DOCK 7 is a 2,140 amino acid protein that localizes to developing axons and contains one DHR-1 domain and one DHR-2 domain. Expressed in a variety of tissues, DOCK 7 functions as a guanine nucleotide exchange factor (GEF) that specifically activates Rac 1 and Rac 3 by catalyzing the exchange of bound GDP for free GTP. Multiple isoforms of DOCK 7 exist due to alternative splicing events. Function: DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. Subunit: Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3. Subcellular Location: Cell projection, Tissue Specificity: Widely expressed. Similarity: Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Database links: Entrez Gene: 85440 Human GenBank: BC016392.1 Human SwissProt: Q96N67 Human Unigene: 406156 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DOCK 7是2140个氨基酸蛋白，定位于发育轴突，包含一个DHR-1结构域和一个DHR-2结构域。在多种组织中表达，DOCK 7作为鸟嘌呤核苷酸交换因子（GEF）发挥作用，通过催化结合GDP交换游离GTP而特异性激活Rac 1和Rac 3。多个异构体的坞7由于选择性剪接事件存在。