• 经测试应用IHC-P, WBmore details
• 种属反应性
  与反应: Rat, Human
• 免疫原

  Recombinant full length protein corresponding to Human AKR1C3.
  Database link: P42330

• 阳性对照
  • K562, Jurkat, HepG2, A549 and SW620 cell extracts; Human esophageal cancer, rat kidney and rat brain tissues.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
• 存储溶液pH: 7.40
  Preservative: 0.02% Sodium azide
  Constituents: 49% PBS, 50% Glycerol, 0.87% Sodium chloride
  
  PBS without Mg²⁺ and Ca²⁺.
• 浓度100 µl 浓度为 1 mg/ml 
  
• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
   
  • Growth Factors/Hormones
   
  • Hormones

  • Signal Transduction
   
  • Metabolism
   
  • Energy Metabolism

  • Neuroscience
   
  • Endocrine system
   
  • Gonadotrophic axis

  • Metabolism
   
  • Pathways and Processes
   
  • Metabolic signaling pathways
  • Energy transfer pathways
   
  • Energy Metabolism

应用

靶标

• 功能Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
• 组织特异性Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
• 序列相似性Belongs to the aldo/keto reductase family.
• 细胞定位Cytoplasm.
• Information by UniProt
• 数据库链接
  • Entrez Gene: 8644 Human
  • Entrez Gene: 307092 Rat
  • Omim: 603966 Human
  • SwissProt: P42330 Human
  • Unigene: 78183 Human
  • Unigene: 10030 Rat
• 别名
  • 17 beta HSD 5 antibody
  • 17 beta hydroxysteroid dehydrogenase type 5 antibody
  • 17-beta-HSD 5 antibody

  see all

Anti-AKR1C3 antibody 图像

• 

  Western blot - Anti-AKR1C3 antibody (ab196673)
  All lanes : Anti-AKR1C3 antibody (ab196673) at 1/500 dilution
  
  Lane 1 : K562 cell extract
  Lane 2 : Jurkat cell extract
  Lane 3 : HepG2 cell extract
  Lane 4 : A549 cell extract
  Lane 5 : SW620 cell extract
  
  
  Predicted band size : 37 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AKR1C3 antibody (ab196673)

  Immunohistochemical analysis of paraffin-embedded Human esophageal cancer tissue labeling AKR1C3 with ab196673 at 1/100 dilution.

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AKR1C3 antibody (ab196673)

  Immunohistochemical analysis of paraffin-embedded rat kidney tissue labeling AKR1C3 with ab196673 at 1/100 dilution.

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AKR1C3 antibody (ab196673)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue labeling AKR1C3 with ab196673 at 1/100 dilution.