DCUN1D1,鳞状细胞癌相关蛋白抗体

产品编号HZ-14306R
英文名称DCUN1D1
中文名称鳞状细胞癌相关蛋白抗体
别 名DCN1 defective in cullin neddylation 1 domain containing 1; DCN1 like protein 1; DCNL1; DCNL1_HUMAN; DCUN1 domain containing protein 1; DCUN1L1; Defective in cullin neddylation protein 1 like protein 1; RP 42; RP42; RP42 homolog; SCCRO; SCRO; Squamous cell carcinoma related oncogene; Tes 3; Tes3.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 肿瘤细胞生物标志物 泛素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Chicken, Cow, Horse,
DCUN1D1,鳞状细胞癌相关蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量30kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DCUN1D1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DCUN1D1,鳞状细胞癌相关蛋白抗体PubMedPubMed
产品介绍background:
DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

Gene ID:
54165

DCUN1D1,鳞状细胞癌相关蛋白抗体Database links:
Entrez Gene: 54165 Human
Entrez Gene: 424963 Chicken
Entrez Gene: 539869 Cow
Entrez Gene: 114893 Mouse
Entrez Gene: 327232 Zebrafish
Omim: 605905 Human
SwissProt: Q5ZKU1 Chicken
SwissProt: Q96GG9 Human
SwissProt: Q9QZ73 Mouse
Unigene: 104613 Human
Unigene: 374810 Mouse
Unigene: 379305 Mouse
Unigene: 474495 Mouse
Unigene: 113807 Zebrafish

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.