Repulsive Guidance Molecule B,反义导向分子RGMB抗体

产品编号HZ-11474R
英文名称Repulsive Guidance Molecule B
中文名称反义导向分子RGMB抗体
别 名RGMB; Dragon; DRG11-responsive axonal guidance and outgrowth of neurite; Repulsive Guidance Molecule B; RGM b; RGM domain family member B; Rgmb; RGMB_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 干细胞 细胞表面分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
Repulsive Guidance Molecule B,反义导向分子RGMB抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Repulsive Guidance Molecule B,反义导向分子RGMB抗体PubMedPubMed
产品介绍background:
The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).

Function:
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.

Subunit:
Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Membrane raft

Post-translational modifications:
GPI-anchored.

Similarity:
Belongs to the repulsive guidance molecule (RGM) family.

Database links:
Entrez Gene: 285704 Human
Entrez Gene: 68799 Mouse
Omim: 612687 Human
SwissProt: Q6NW40 Human
SwissProt: Q7TQ33 Mouse
Unigene: 526902 Human
Unigene: 293466 Mouse

Repulsive Guidance Molecule B,反义导向分子RGMB抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.