PLAGL1,多型性腺瘤基因样蛋白1抗体

产品编号HZ-11206R
英文名称PLAGL1
中文名称多型性腺瘤基因样蛋白1抗体
别 名DKFZp781P1017; Lost on transformation 1; Lost on Transformation; LOT-1; LOT1; MGC126275; MGC126276; PLAG like 1; PLAGL1; PLAL1_HUMAN; Pleiomorphic adenoma gene like 1; Pleiomorphic adenoma gene like protein 1; Pleiomorphic adenoma-like protein 1; Tumor supressor ZAC; ZAC; ZAC tumor supressor; ZAC1; Zinc finger protein PLAGL1.
说 明 书0.1ml 0.2ml
研究领域神经生物学 干细胞 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Zebrafish,
PLAGL1,多型性腺瘤基因样蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PLAGL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PLAGL1,多型性腺瘤基因样蛋白1抗体PubMedPubMed
产品介绍background:
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010].

Function:
Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.

Subunit:
Interacts with THRSP.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 7 C2H2-type zinc fingers.

Database links:
Entrez Gene: 5325 Human
Entrez Gene: 22634 Mouse
Entrez Gene: 25157 Rat
Entrez Gene: 421664 Chicken
Omim: 603044 Human
SwissProt: Q9UM63 Human
Unigene: 725973 Human
Unigene: 287857 Mouse
Unigene: 6977 Rat

PLAGL1,多型性腺瘤基因样蛋白1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.