ABI1/SSH3BP1,ABI1/SSH3BP1蛋白抗体

产品编号HZ-1961R
英文名称ABI1/SSH3BP1
中文名称ABI1/SSH3BP1蛋白抗体
别 名Abelson interactor 1; Abelson interactor 1; ABI 1; ABI1; ABI-1 Abl binding protein 4; Abl interactor 1; Abl interactor protein 1 long; AblBP4; Ablphilin 1; E3B1; Eps8 binding protein; Eps8 SH3 domain binding protein; Hssh3bp1; NAP1; NAP1BP; Spectrin SH3 domain binding protein 1; SSH3BP; SSH3BP1; ABI1_HUMAN.
规格价格0.1ml0.2ml
说 明 书0.1ml 0.2ml
研究领域免疫学 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit,
ABI1/SSH3BP1,ABI1/SSH3BP1蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
细胞定位细胞核 细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ABI1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ABI1/SSH3BP1,ABI1/SSH3BP1蛋白抗体PubMedPubMed
产品介绍background:
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus(v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.

Function:
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus(v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.

Subunit:
Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1. Interacts with SOS1, SOS2, GRB2, SPTA1 and the first SH3 domain of NCK1. Isoform 6 does not interact with NCK1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2.

ABI1/SSH3BP1,ABI1/SSH3BP1蛋白抗体Subcellular Location:
Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes.

Tissue Specificity:
Widely expressed, with highest expression in brain.

Post-translational modifications:
In vitro substrate for v-Abl. Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl.

Similarity:
Belongs to the ABI family. Contains 1 SH3 domain. Contains 1 t-SNARE coiled-coil homology domain.

Gene ID:
10006

Database links:
Entrez Gene: 10006 Human
Entrez Gene: 11308 Mouse
Entrez Gene: 79249 Rat
Omim: 603050 Human
SwissProt: Q8IZP0 Human
SwissProt: Q8CBW3 Mouse
SwissProt: A2VD09 Rat
SwissProt: Q9QZM5 Rat
Unigene: 508148 Human
Unigene: 205647 Mouse
Unigene: 249752 Mouse
Unigene: 43675 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.