FITC标记的透明质酸结合蛋白1抗体
产品名称： FITC标记的透明质酸结合蛋白1抗体
英文名称： Anti-GC1q R/FITC
产品编号： HZ-11263R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GC1q R/FITC Conjugated antibody
FITC标记的透明质酸结合蛋白1抗体
| 产品编号 | bs-11263R-FITC |
| 英文名称 | Anti-GC1q R/FITC |
| 中文名称 | FITC标记的透明质酸结合蛋白1抗体 |
| 别 名 | C1q globular domain binding protein; C1QBP; GC1q R; C1QBP_HUMAN antibody Complement component 1 q subcomponent binding protein; Complement component 1 Q subcomponent binding protein mitochondrial; Complement component 1 Q subcomponent-binding protein, mitochondrial; GC1Q R; GC1q R protein; GC1q-R protein; GC1QBP; GC1QR; Glycoprotein gC1qBP; HABP 1; HABP1; Hyaluronan binding protein 1; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p32 antibody p33 antibody Pre mrna splicing factor SF2 P32 subunit precursor; SF2p32; Splicing factor SF2 associated protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C1QBP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system (SCS). The SCS contains over 30 glycoproteins that influence physiological mechanisms of the body in response to immune complex (the classical pathway), carbohydrate (the lectin pathway) or bacterial (alternative pathway) initiation. C1q binding protein (C1QBP), also designated gC1q-R, p32 (p33) or HABP1 (hyaluronan-binding protein 1), is known to bind the globular heads of C1q molecules and inhibit C1 activation. C1QBP has been described as a complement receptor for C1q on B cells, neutrophils and mast cells. The C1QBP protein may form homodimers. C1QBP is expressed in vascular endothelial cells and has been found to be a multifunctional protein interacting with elements of complement, coagulation and kinin systems. In addition, C1QBP is a subunit of pre-mRNA splicing factor SF2/ASF. Function: Binds to the globular "heads" of C1Q thus inhibiting C1 activation. Subunit: Homotrimer; three monomers form a donut-shaped structure with an unusually asymmetric charge distribution on the surface. Interacts with CDK13, HRK, VTN, NFYB, ADRA1B, FOXC1, DDX21, DDX50, NCL, SRSF1, SRSF9 and CDKN2A isoform smARF. Interacts with CD93; the association may represent a cell surface C1q receptor. Interacts with KRT1; the association represents a cell surface kininogen receptor. Interacts with CD209; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. Interacts with FBL and RRP1; the respective interactions with C1QBP are competetive. Probably associates with the mitoribosome. Interacts with MAVS; the interaction occurs upon viral tansfection. Interacts with PPIF. Interacts with Rubella virus capsid protein; the interaction occurs in mitochondria. Interacts with Rubella virus protease p150, Staphylococcus aureus protein A/spa, HIV-1 Tat and HCV core protein. Subcellular Location: Mitochondrion matrix. Nucleus. Might also be nuclear in some cell types. Tissue Specificity: Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells. Similarity: Belongs to the MAM33 family. Database links: Entrez Gene: 708 Human Entrez Gene: 12261 Mouse Entrez Gene: 29681 Rat Omim: 601269 Human SwissProt: Q07021 Human SwissProt: O35658 Mouse SwissProt: O35796 Rat Unigene: 555866 Human Unigene: 30049 Mouse Unigene: 2765 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
人类补体亚组分C1q与C1R和C1S相关联，以产生血清补体系统（SCS）的第一成分。SCS含有超过30种糖蛋白，其影响机体对免疫复合物（经典途径）、碳水化合物（凝集素途径）或细菌（替代途径）启动的生理机制。C1q结合蛋白（C1QBP），也被命名为GC1Q-R，P32（P33）或HABP1（透明质酸结合蛋白1），已知结合C1q分子的球形头部并抑制C1激活。C1QBP被认为是C1q在B细胞、中性粒细胞和肥大细胞上的补体受体。C1qBP蛋白可能形成同源二聚体。C1QBP在血管内皮细胞中表达，已被发现是与补体、凝血和激肽系统相互作用的多功能蛋白。此外，C1QBP是前mRNA剪接因子SF2/ASF的亚基。