hnRNP C1/C2,异质性核糖核蛋白C1/C2抗体

产品编号HZ-6459R
英文名称hnRNP C1/C2
中文名称异质性核糖核蛋白C1/C2抗体
别 名hnRNP C1 + C2; Heterogeneous nuclear ribonucleoprotein C; Heterogeneous nuclear ribonucleoproteins C1/C2; HNRNP; hnRNP C1 / hnRNP C2; hnRNPC; HNRPC; HNRPC_HUMAN; Nuclear ribonucleoprotein particle C1 protein; Nuclear ribonucleoprotein particle C2 protein; SNRPC.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
hnRNP C1/C2,异质性核糖核蛋白C1/C2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human HNRPC
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
hnRNP C1/C2,异质性核糖核蛋白C1/C2抗体PubMedPubMed
产品介绍background:
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.

Function:
UniProtKB/Swiss-Prot: P07910.4

Subunit:
Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1.

Subcellular Location:
Nucleus. Component of ribonucleosomes.

hnRNP C1/C2,异质性核糖核蛋白C1/C2抗体Post-translational modifications:
Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
Sumoylated. Sumoylation reduces affinity for mRNA.

Similarity:
Belongs to the RRM HNRPC family. RALY subfamily.
Contains 1 RRM (RNA recognition motif) domain.

Gene ID:
3183

Database links:
Entrez Gene: 3183 Human
Entrez Gene: 15381 Mouse
Entrez Gene: 290046 Rat
Omim: 164020 Human
SwissProt: P07910 Human
SwissProt: Q9Z204 Mouse
SwissProt: P17132 Rat
Unigene: 508848 Human
Unigene: 675546 Human
Unigene: 427321 Mouse
Unigene: 473169 Mouse
Unigene: 101929 Rat

hnRNP C1/C2,异质性核糖核蛋白C1/C2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.