DNA polymerase delta p50,DNA聚合酶δ2/DNA pol δ 2抗体

产品编号HZ-13014R
英文名称DNA polymerase delta p50
中文名称DNA聚合酶δ2/DNA pol δ 2抗体
别 名DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; POLD2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Macaque Monkey
DNA polymerase delta p50,DNA聚合酶δ2/DNA pol δ 2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DNA polymerase delta p50
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DNA polymerase delta p50,DNA聚合酶δ2/DNA pol δ 2抗体PubMedPubMed
产品介绍background:
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012].

Function:
The function of the small subunit is not yet clear.

Subunit:
Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with KCTD10 (By similarity). Interacts with KCTD13/POLDIP1, POLDIP2 and POLDIP3. Interacts with WRNIP1. Interacts with POLD4.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the DNA polymerase delta/II small subunit family.

Database links:
UniProtKB/Swiss-Prot: P49005.1

DNA polymerase delta p50,DNA聚合酶δ2/DNA pol δ 2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.