FITC标记的组蛋白赖氨酸N-甲基EZH1抗体
产品名称： FITC标记的组蛋白赖氨酸N-甲基EZH1抗体
英文名称： Anti-EZH1/FITC
产品编号： HZ-6528R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-EZH1/FITC Conjugated antibody
FITC标记的组蛋白赖氨酸N-甲基EZH1抗体
| 英文名称 | Anti-EZH1/FITC |
| 中文名称 | FITC标记的组蛋白赖氨酸N-甲基EZH1抗体 |
| 别 名 | Enhancer of zeste homolog 1(Drosophila); Enhancer of zeste homolog 1; ENX-2; ENX2; EZH1; EZH1: enhancer of zeste homolog 1 (Drosophila); EZH1_HUMAN; Histone-lysine N-methyltransferase EZH1; KIAA0388. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 染色质和核信号 肿瘤细胞生物标志物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 85kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EZH1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Sequence similarities Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1 SET domain. Function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Subunit: Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM). Subcellular Location: Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3. Similarity: Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1 CXC domain. Contains 1 SET domain. Database links: Entrez Gene: 2145 Human Entrez Gene: 14055 Mouse Entrez Gene: 303547 Rat Omim: 601674 Human SwissProt: Q92800 Human SwissProt: P70351 Mouse Unigene: 194669 Human Unigene: 5027 Mouse Unigene: 154549 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
多梳组蛋白（PCG）。PRC2/ED-EZH1复合物的催化亚基，其甲基化了组蛋白H3的“LYS－27”，导致受影响的靶基因的转录抑制。能够将组蛋白H3的单、二和三甲基酯“LYS－27”分别形成H3K27 ME1、H3K27 ME2和H3K27 ME3。胚胎干细胞的衍生和自我更新所需要的，这表明它参与了胚胎干细胞身份的保护。与含EZH1的复合物相比，胚胎干细胞中的甲基转移酶活性较低，在形成H3K27 ME3中起着不太重要的作用，这是胚胎干细胞的身份和正确分化所必需的。
序列相似性
属于组蛋白赖氨酸甲基转移酶家族。EZ亚家族。包含1个集合域。