NMUR2,G蛋白偶联受体FM4/神经调节肽U受体2抗体

产品编号HZ-11421R
英文名称NMUR2
中文名称G蛋白偶联受体FM4/神经调节肽U受体2抗体
别 名FM4; G protein coupled receptor FM 4; G protein coupled receptor TGR 1; G-protein coupled receptor FM-4; G-protein coupled receptor TGR-1; Neuromedin U receptor 2; Neuromedin-U receptor 2; NMU R2; NMU-R2; NMU2R; NMUR2; NMUR2_HUMAN; TGR1; GPR-FM4
说 明 书0.1ml 0.2ml
研究领域肿瘤 神经生物学 细胞膜受体 G蛋白偶联受体 G蛋白信号 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Pig, Cow, Horse, Rabbit, Sheep,
NMUR2,G蛋白偶联受体FM4/神经调节肽U受体2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NMUR2 (181-230aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NMUR2,G蛋白偶联受体FM4/神经调节肽U受体2抗体PubMedPubMed
产品介绍background:
Neuromedin U is a neuropeptide with high activity on smooth muscle. It is widely expressed in gastrointestinal systems and central nervous system (CNS). Peripheral activities of neuromedin U include smooth muscle stimulation, ion transport alterations in the gut and the regulation of local blood flow and adrenocortical function. Neuromedin U receptors 1 and 2 (NMUR1 and NMUR2) are multi-pass membrane proteins that belong to the G-protein coupled receptor 1 family of proteins. Both NMUR1 and NMUR2 act as receptors for the neuromedin U neuropeptide. NMUR1 is detected in peripheral organs, particularly in urogenital and gastrointestinal systems, with highest levels in testis. It’s expression in CNS is low, but the protein has been detected in cerebellum, hippocampus, dorsal root ganglia and spinal cord. NMUR2 is predominantly detected in central nervous system with highest levels detected in medulla oblongata, spinal cord and thalamus. It may also be detected in testis but has low levels of expression in peripheral tissues.

Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

NMUR2,G蛋白偶联受体FM4/神经调节肽U受体2抗体Database links:
Entrez Gene: 56923 Human
Omim: 605108 Human
SwissProt: Q9GZQ4 Human
Unigene: 283093 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.