淋巴瘤基因表达PCR芯片

     淋巴瘤基因表达PCR芯片可用于研究与淋巴瘤发展，疾病分型，预后以及治疗反应中关键的84个基因的表达。该芯片包含有和淋巴瘤相关的信号通路包括细胞黏附，细胞周期，免疫以及炎症反应，PI3K/AKT，T细胞分化的关键基因；芯片上还包含有这些通路中淋巴瘤治疗靶标，淋巴瘤样品中常规检测的基因以及启动子发生甲基化变化的基因。利用该芯片，研究者可以方便并且可信地对与淋巴瘤发生发展以及转移相关的基因进行同时检测。

Differentially Methylated Promoters: AFF1, ATM, CADM1 (TSLC1), CCND1, CDH1 (E-Cadherin), CDH13, CDKN1C (p57KIP2), CDKN2B (p15INK4B), CDKN2C (p18INK4C), DAPK1, DLC1, FHIT, GSTP1, HIC1, HRK, ID4, LRP1B, MLH1, MYOD1, RASSF1, RBP1, SLC19A1, TIMP2, TIMP3.

DLBCL Survival: ASB13, BCL6, ITPKB, LMO2, LRMP, MYBL1, PAG1, PTK2, TTC9, VGLL4.

Follicular Lymphoma Survival: C1QA, CCR1, F8, FCGR1A, FLT3LG, STAT4, TLR5, TNFRSF1B, TNFSF13B.

Lymphoma Therapeutic Targets: BCL6, BIRC5, BTK, CD22, CD40 (TNFRSF5), CD80, CXCR4, FCGR1A, HSP90AA1, MCL1, MS4A1, MTOR, NOTCH1, PARP1 (ADPRT1), PTK2, SRC, SYK, TGFB1, TNFSF13B.

Inflammatory Response: C1QA, CCR1, CD40 (TNFRSF5), CD40LG (TNFSF5), CSF3 (GCSF), CXCR4, F8, IL6, NFKB1, TGFB1, TLR5, TNF, TNFRSF1B.

Immune System Process: BCL6, C1QA, CADM1 (TSLC1), CD2, CD4, CD40 (TNFRSF5), CD5, CD79A, CD80, FCER2, IFNG, IL2, IL6, ITPKB, PDLIM7, PTPRC, SYK, TGFB1, TNFSF13B.

T Cell Differentiation: BCL2, CD3D, CD4, CD8A, ITPKB, IL2, PTPRC, SYK, TGFB1, TP53.

Cell Adhesion: BCL2, CADM1 (TSLC1), CCR1, CD2, CD22, CD34, CD4, CD40LG (TNFSF5), CD47, CD8A, CDH1 (E-Cadherin), CDH13, DLC1, F8, IL2, NCAM1, PTPRC, SRC, SYK, TNF.

Cell Cycle: ATM, BCL2, BIRC5, CCND1, CDKN1C (p57KIP2), CDKN2B (p15INK4B), CDKN2C (p18INK4C), ID4, IFNG, MKI67, MLH1, MYC, RASSF1, TGFB1, TP53.

PI3K/ AKT Signaling: ALK, BCL2, BTK, CCND1, CCR1, CD2, CD4, CD40 (TNFRSF5), CD40LG (TNFSF5), CSF3 (GCSF), CXCR4, HSP90AA1, IL2, IL6, MTOR, PTK2, SYK, TGFB1, TIMP2, TIMP3, TNFRSF1B, TNFSF13B, TP53.

Gene Fusion: ALK, MME.

DNA RePAir: DNTT.