MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Sivelestat
CAS No. : 127373-66-4
MCE 国际站：Sivelestat
产品活性：Sivelestat (EI546) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其 IC50 值为 44 nM， Ki 值为 200 nM。Sivelestat (EI546) 有潜力用于 COVID-19 的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。
研究领域：Metabolic Enzyme/Protease | Anti-infection
In Vitro: Sivelestat (ONO-5046) does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM.
Sivelestat (ONO-5046) exhibits IC50 values of 44 nM, 36 nM, 19 nM, 37 nM and 49 nM for human, rabbit, rat, hamster and mouse neutrophil elastase, respectively.
In Vivo: Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamster (ID50 = 82 pg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which are induced by human neutrophil elastase.
Sivelestat (10 mg/kg, infusion via the tail vein) ameliorates lung injury after hemorrhagic shock in rats.
Sivelestat (15, 60 mg/kg, ip) prevents ischemia–reperfusion injury in the rat bladder.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Metabolism/Protease Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Antiviral Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | FDA Approved & Pharmacopeial Drug Library | Rare Diseases Drug Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Non-steroidal Anti-Inflammatory Compound Library | Coagulation and Anti-coagulation Compound Library | Off-patent Drug Library | Protease Inhibitor Library | Multi-Target Compound Library | Bioactive Compound Library Max | Chloroquine | Dexamethasone | Thapsigargin | ALC-0315 | Imatinib | Nirmatrelvir | Aloxistatin | Imiquimod | Hydroxychloroquine | Remdesivir | Paquinimod | Brequinar | GSK3326595 | Auranofin | Molnupiravir | Favipiravir | Ritonavir | Methylprednisolone | Ivermectin | Emodin | Elastase, Porcine pancreas | Punicalagin | Asunaprevir | Camostat mesylate | Cepharanthine | Zotatifin | Grazoprevir
热门产品线：重组蛋白 | 药物筛选 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
• 提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。
